MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias
نویسندگان
چکیده
منابع مشابه
MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias
CXCR4 is a negative prognostic marker in acute myeloid leukemias (AMLs). Therefore, it is necessary to develop novel ways to inhibit CXCR4 expression in leukemia. AMD3100 is an inhibitor of CXCR4 currently used to mobilize cancer cells. CXCR4 is a target of microRNA (miR)-146a that may represent a new tool to inhibit CXCR4 expression. We then investigated CXCR4 regulation by miR-146a in primary...
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ژورنال
عنوان ژورنال: Blood Cancer Journal
سال: 2011
ISSN: 2044-5385
DOI: 10.1038/bcj.2011.24